doi:10./j.athoracsur..0..
背景本研究旨在探讨术前单次小剂量甲基强的松龙(MP)对全麻下择期电视胸腔镜手术患者免疫功能及术后疼痛的影响。方法将81例择期电视胸腔镜手术患者随机分为MP组和对照组。记录T淋巴细胞亚群CD3+、CD+、CD8+、T0(麻醉前)、T1(术后)、T2(术后2h)CD+/CD8+比值。同时记录术后休息和咳嗽疼痛评分,以及术后不良反应和手术并发症。结果与T0相比,两组患者术后CD3+、CD+亚群及CD+/CD8+水平均明显下降,两组CD8+水平均升高。MP组与对照组CD3+、CD+、CD8+、CD+/CD8+变化无显著性差异。术后2、、6、2h,MP组患者的静息痛和咳嗽痛均明显低于对照组。对照组恶心、呕吐、头晕的发生率也明显高于MP组。结论术前单次小剂量MP(1mg/kg)对机体免疫功能无影响。术前单次小剂量MP(1mg/kg)可提供有效镇痛,可降低术后头晕及恶心呕吐的发生率。原始文献AbstractBackgroundThepurposeofthisstudywastoevaluatetheeffectsofsinglelow-dosepreoperativemethylprednisolone(MP)ontheimmunologicalfunctionandpostoperativepainofpatientsundergoingelectivevideo-assistedthoracoscopicsurgeryundergeneralanesthesia.
MethodsEighty-onepatientswhounderwentelectivevideo-assistedthoracoscopicsurgerywererandomlyassignedtotheMPGrouportheControlGroup.TheTlymphocytesubsetsofCD3+,CD+,andCD8+,theCD+/CD8+ratioatT0(beforeanesthesia),T1(aftersurgery),andT2(2haftersurgery)wereallrecorded.Postoperativerestandcoughpainscores,aswellaspostoperativeadverseeffectsandsurgery
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